Estimation and Reliability of Molecular Sequence Alignments
نویسندگان
چکیده
منابع مشابه
Estimation and reliability of molecular sequence alignments.
The problem of estimating the relatedness of a pair of biological sequences is addressed. A stochastic model of sequence evolution is described that allows insertion and deletion as well as replacement of amino acid residues (or substitution of nucleotides) over time. An expectation-maximization (EM) algorithm that obtains maximum likelihood estimates of the model parameters is introduced. The ...
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ژورنال
عنوان ژورنال: Biometrics
سال: 1995
ISSN: 0006-341X
DOI: 10.2307/2533318